Fast-Acting Sleep Support
Bodhi Health’s Fast-Absorbing Sublingual Melatonin (Sleep) quickly dissolves under your tongue delivering melatonin directly into your bloodstream within minutes.
This provides a fast-acting effect that is facilitated by our proprietary oral strip technology, which is proven to delivery active ingredients into the bloodstream rapidly, once placed under the tongue (1).
Approved Benefits of Melatonin:
- Helps increase total sleep time in people suffering from sleep restriction or altered sleep schedule (e.g., shift work and jet lag).
- Helps to reduce the time it takes to fall asleep.
- Helps to reset the body’s sleep-wake-cycle.
- Natural, safe and non-habit-forming sleep aid.
Why Is Sublingual Melatonin the Best Route of Administration?
Clinical studies show that oral melatonin supplements that you swallow are not absorbed well from the gut. In fact, some studies show that only 15% of the melatonin you swallow gets absorbed from the intestinal tract into the bloodstream (this also includes melatonin being quickly broken down by liver enzymes shortly after its absorption form the intestinal tract) (2) As such, oral melatonin supplements are a very inefficient approach to the use of melatonin as a sleep aid or to reset the body’s sleep-wake cycle.
Other Important Reasons to Consider Melatonin (Sleep) Use After Age 40:
Age-related Decline in Melatonin Synthesis - Melatonin levels begin to decline in the body after puberty and by age 40 melatonin levels are more than 50% lower than they were at age 12-13. This is important because, in addition to sleep benefits, the body relies on melatonin for other important functions (Frontiers of Aging Neuroscience 2022.
https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2022.888292/full).
Some of these functions include the following:
Immune Support – many immune cells contain melatonin receptors that require melatonin stimulation for immune cells to function optimally throughout our lifetime (3).
Protects Brain Cells from Free Radical Damage: Melatonin is a very important antioxidant in the brain, protecting brain cells from the damaging effects of free radicals that are involved in a variety of neurodegenerative diseases and brain aging (4),
Small Studies Show Improvement in Early-Stage Memory Loss: Several human studies have shown that patients with early-stage memory loss (mild cognitive impairment) exhibited significantly better performance in the Mini-Mental State Examination and the Cognitive Subscale of Alzheimer’s disease Assessment Scale after melatonin administration compared to the control group (who did not receive melatonin) (5).
Prostate and Breast Health Support: Prostate and Breast cells are known to possess melatonin receptors. When melatonin binds to these receptors it enters these cells where it is shown to exert a numerous health-promoting effects of importance (6,7).
Turns-On Anti-Aging Sirtuin Genes – Experimental studies show that melatonin “turns on” (upregulates) anti-aging genes in human cells known as sirtuin genes (SIRT 1). Sirtuin gene activation is shown to help protect us against various age-related conditions and degenerative states associated with the aging process (8,9,10)
References:
- Breakthrough Proprietary Oral Film Technology: (Frontiers of Pharmacology, 2019.
https://pubmed.ncbi.nlm.nih.gov/31551785/), - DeMuro RL et al. The absolute bioavailability of oral melatonin. J Clin Pharmacol.2000;40(7):781-4
https://pubmed.ncbi.nlm.nih.gov/10883420/ - Carrillo-Vico A. et al. Melatonin: Buffering the immune system. Int J Sci. 2023;14(4):8638-8683.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3645767/ - Goo Lee J et al. The neuroprotective effects of melatonin: Possible role in the pathophysiology of neuropsychiatric disease. Brain Sci. 2019;9(10):285. https://pmc.ncbi.nlm.nih.gov/articles/PMC6826722/
- Cardinali D.P., et al. Therapeutic application of melatonin in mild cognitive impairment. Am J Neurodegener Dis. 2012;1(3):280-291. https://pmc.ncbi.nlm.nih.gov/articles/PMC3560473/
- Megerian M.F. et al. Melatonin and Prostate Cancer : Anti-tumor roles and therapeutic application. Aging Dis. 2023;14(3):840-857. https://pmc.ncbi.nlm.nih.gov/articles/PMC10187692/
- Grant S.G. et al. Melatonin and breast cancer: Cellular mechanisms, clinical studies and future perspectives. Expert Rev Mol Med. 2009;11:e5. https://pmc.ncbi.nlm.nih.gov/articles/PMC4301735/
- Qin K et al. Melatonin promotes sirtuin 1 expression and inhibits IRE1-alpha-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes. Front. Pharmacol. 2022;13.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.940629/full - Rodrguez-Santana C et al. The relationship between clock genes, sirtuin 1, and mitochondrial activity in head and neck squamous cell cancer: Effects of melatonin treatment. Int J Mol Sci. 2023;24(19): 15030.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.940629/full - Mayo J.C. et al. Melatonin and sirtuins : A “not-so unexpected” relationship. J Pineal Research. 2017;62e 12391. https://digibuo.uniovi.es/dspace/bitstream/handle/10651/43022/jpi.12391.pdf?sequence=1
