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Experimental studies suggest that curcumin exerts other important protective effects on brain cells, potentially blocking steps involved in several age-related neurodegenerative conditions (2).\u003c\/p\u003e\n\u003cp\u003eThe Challenge:\u003c\/p\u003e\n\u003cp\u003eCurcumin has very low absorption when taken orally—only 1–2% enters the bloodstream. Only small amounts are active even at high doses (1200–3000 mg\/day) (4). This limits its effectiveness for severe pain or inflammation, often leading patients to rely on other medications.\u003c\/p\u003e\n\u003cp\u003eThe Bodhi Health Breakthrough Solution\u003c\/p\u003e\n\u003cp\u003eTo overcome the problems of poor absorption (bioavailability) and high-dose administration (1200 mg per day), Bodhi Health has developed a breakthrough patented Curcumin that provides for fast sublingual absorption (under the tongue). This innovative delivery system allows curcumin to enter the bloodstream within minutes, bypassing digestion and first-pass liver metabolism. This is also made possible using our proprietary oral film strip technology, which in published human research is shown to significantly increase blood levels of active constituents within minutes following sublingual administration (1,5)\u003c\/p\u003e\n\u003cp\u003eKey Advantages:\u003c\/p\u003e\n\u003cp\u003e• Direct bloodstream absorption through the oral mucosa\u003c\/p\u003e\n\u003cp\u003e• Bypasses gut and liver breakdown, preserving curcumin’s potency\u003c\/p\u003e\n\u003cp\u003e• Fast-acting: elevated blood levels in minutes\u003c\/p\u003e\n\u003cp\u003e• Higher bioavailability than traditional oral supplements\u003c\/p\u003e\n\u003cp\u003eClinical studies using the same sublingual technology show significantly higher blood concentrations at 1-, 10-, and 30-minute post-administration compared to standard oral delivery (5).\u003c\/p\u003e\n\u003cp\u003eReferences:\u003c\/p\u003e\n\u003cp\u003e1. Patented Curcumin Shown to Improve Bioavailability 46x higher than standard curcumin. 2017 US Patent Approval. https:\/\/omniactives.com\/press-releases\/ultrasol-curcumin-line-curcuwin-granted-patent-for-sports-performance-benefits\/ (and https:\/\/patents.google.com\/patent\/WO2012156979A1\/en)\u003c\/p\u003e\n\u003cp\u003e2. Curcumin Crosses Blood-Brain-Barrier Exerting Neuroprotective Effects. Adv Exp Med Biol, 2007. NEUROPROTECTIVE EFFECTS OF CURCUMIN - PMC\u003c\/p\u003e\n\u003cp\u003e3. Curcumin Improves Memory in Subjects 50-90 Years Old Compared to Placebo. Am J Geriatric Psychiatry, 2018. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1064748117305110\u003c\/p\u003e\n\u003cp\u003e4. Typical Poor Bioavailability of Phenolic Compounds (including Curcumin) Scholarly Community Encyclopedia, 2020. https:\/\/encyclopedia.pub\/entry\/3533\u003c\/p\u003e\n\u003cp\u003e5. Breakthrough Proprietary Oral Film Technology: (Frontiers of Pharmacology, 2019. https:\/\/pubmed.ncbi.nlm.nih.gov\/31551785\/),\u003c\/p\u003e","brand":"Bodhi Health Inc","offers":[{"title":"Default Title","offer_id":42365266624602,"sku":"CP400044","price":299.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0676\/2001\/2122\/files\/Curcumin_20_display_a36b2a36-3d3c-4d5d-80a8-3d24fe82beba.jpg?v=1759309683"},{"product_id":"bodhi-curcumin-30-pak-10-box","title":"Curcumin Sublingual 30 Pack - 10 Box Counter Display","description":"\u003cp\u003eBodhi Health has developed a breakthrough patented Curcumin (1) designed for sublingual absorption (under the tongue). This innovative delivery system allows curcumin to enter the bloodstream within minutes, bypassing digestion and first-pass liver metabolism. This enables curcumin to enter the bloodstream quickly and travel to key target tissues to suppress inflammation (and accompanying pain) and provide antioxidant effects.\u003c\/p\u003e\n\u003cp\u003eEffects in the Body Curcumin, a compound in turmeric, has shown powerful anti-inflammatory, neuroprotective, exercise recovery and other important health effects in many studies. Bodhi Health Sublingual Curcumin is approved by health Canada for the purpose of supporting joint health and suppressing joint inflammatory conditions (i.e., osteoarthritis, other arthritic conditions, joint, muscle, tendon injuries etc.)\u003c\/p\u003e\n\u003cp\u003eCurcumin is also shown to cross the blood-brain-barrier, where it provides documented neuroprotective effects (brain protective effects). Some small studies show that it improves memory and recall ability in healthy older subjects (2, 3). Experimental studies suggest that curcumin exerts other important protective effects on brain cells, potentially blocking steps involved in several age-related neurodegenerative conditions (2).\u003c\/p\u003e\n\u003cp\u003eThe Challenge:\u003c\/p\u003e\n\u003cp\u003eCurcumin has very low absorption when taken orally—only 1–2% enters the bloodstream. Only small amounts are active even at high doses (1200–3000 mg\/day) (4). This limits its effectiveness for severe pain or inflammation, often leading patients to rely on other medications.\u003c\/p\u003e\n\u003cp\u003eThe Bodhi Health Breakthrough Solution\u003c\/p\u003e\n\u003cp\u003eTo overcome the problems of poor absorption (bioavailability) and high-dose administration (1200 mg per day), Bodhi Health has developed a breakthrough patented Curcumin that provides for fast sublingual absorption (under the tongue). This innovative delivery system allows curcumin to enter the bloodstream within minutes, bypassing digestion and first-pass liver metabolism. This is also made possible using our proprietary oral film strip technology, which in published human research is shown to significantly increase blood levels of active constituents within minutes following sublingual administration (1,5)\u003c\/p\u003e\n\u003cp\u003eKey Advantages:\u003c\/p\u003e\n\u003cp\u003e• Direct bloodstream absorption through the oral mucosa\u003c\/p\u003e\n\u003cp\u003e• Bypasses gut and liver breakdown, preserving curcumin’s potency\u003c\/p\u003e\n\u003cp\u003e• Fast-acting: elevated blood levels in minutes\u003c\/p\u003e\n\u003cp\u003e• Higher bioavailability than traditional oral supplements\u003c\/p\u003e\n\u003cp\u003eClinical studies using the same sublingual technology show significantly higher blood concentrations at 1-, 10-, and 30-minute post-administration compared to standard oral delivery (5).\u003c\/p\u003e\n\u003cp\u003eReferences:\u003c\/p\u003e\n\u003cp\u003e1. Patented Curcumin Shown to Improve Bioavailability 46x higher than standard curcumin. 2017 US Patent Approval. https:\/\/omniactives.com\/press-releases\/ultrasol-curcumin-line-curcuwin-granted-patent-for-sports-performance-benefits\/ (and https:\/\/patents.google.com\/patent\/WO2012156979A1\/en)\u003c\/p\u003e\n\u003cp\u003e2. Curcumin Crosses Blood-Brain-Barrier Exerting Neuroprotective Effects. Adv Exp Med Biol, 2007. NEUROPROTECTIVE EFFECTS OF CURCUMIN - PMC\u003c\/p\u003e\n\u003cp\u003e3. Curcumin Improves Memory in Subjects 50-90 Years Old Compared to Placebo. Am J Geriatric Psychiatry, 2018. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1064748117305110\u003c\/p\u003e\n\u003cp\u003e4. Typical Poor Bioavailability of Phenolic Compounds (including Curcumin) Scholarly Community Encyclopedia, 2020. https:\/\/encyclopedia.pub\/entry\/3533\u003c\/p\u003e\n\u003cp\u003e5. Breakthrough Proprietary Oral Film Technology: (Frontiers of Pharmacology, 2019. https:\/\/pubmed.ncbi.nlm.nih.gov\/31551785\/),\u003c\/p\u003e","brand":"Bodhi Health Inc","offers":[{"title":"Default Title","offer_id":42365331734618,"sku":"CP400013","price":349.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0676\/2001\/2122\/files\/Curcumin_30_display_98fbbd48-e8f6-4cfa-b803-31f3f4c5bbb6.jpg?v=1759309711"},{"product_id":"bodhi-health-vitamin-b12-sublingual-1000mcg-5-pak","title":"Bodhi Health Vitamin B12 Sublingual, 5 Pack, 20 Sleeve Counter Display","description":"\u003cp\u003eRapid Absorption into the Bloodstream\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnsure Your B12 Status Remains Optimal with Our Fast-Dissolving Sublingual (under the tongue) B12 Strips\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin B12 is a vital nutrient required by the body to make red blood cells (preventing anemia), which enables optimal energy production every minute of our lives. B12 is also necessary for the synthesis of brain chemicals (neurotransmitters) required for normal cognition, focus, mood stabilization, prevention of depression and to prevent the build-up of heart disease promoting “homocysteine” in the bloodstream, among other important function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy Is Sub-Optimal Vitamin B12 Status So Common?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAging Process\u003c\/strong\u003e – in the aging process the stomach makes less acid (hydrochloric acid), which hinders the synthesis and secretion of intrinsic factor. Intrinsic factor is essential for vitamin B12 to get absorbed from the intestinal tract to the bloodstream. As such, many older persons absorb less vitamin B12 from the gut even if they take B12 supplements or consume B12-containing foods frequently.\u003c\/p\u003e\n\u003cp\u003eThis is why Bodhi Health’s Fast Dissolving Sublingual B12 Strips is so helpful for people over 45-50. The fast-dissolving strip allows vitamin B12 to get absorbed directly into the bloodstream once placed under the tongue, without the need of intrinsic factor. Our proprietary oral film strip allows for the fastest possible absorption of B12 (less than one minute in most cases) right into the bloodstream, helping to ensure optimal Vitamin B12 status in your body each day.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntacid Medications\u003c\/strong\u003e - Doctors often prescribe antacids, proton pump inhibitors and\/or histamine blockers to help older subjects who have digestive problems or reflux pain following meals. These drugs block the secretion or action of stomach acids, which in turn further reduces the secretion of intrinsic factor. Intrinsic factor is essential for the absorption of vitamin B12 from the intestinal tract into the bloodstream. Thus, patients taking these drugs are known to be at risk for vitamin B12 deficiency or sub-optimal vitamin B12 status. The daily use of Bodhi Health’s Sublingual B12 is the natural solution to prevent a decline in B12 status in these cases, as our Vitamin B12 strip is quickly absorbed (usually less than one minute) under the tongue directly into the bloodstream, bypassing the need for intrinsic factor.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChanges in Food Selection in Older Subjects and Shifts to More Plant-based Diets\u003c\/strong\u003e – It is well known that older subjects tend to eat fewer vitamin B12 containing foods (mostly meat-based foods) or smaller portions of these foods. This often leads to a significant decline in B12 status over time. As well, even though a more plant-based diet is desirable to help reduce risk of heart disease (cardiovascular disease) and certain cancers, there is no or very little vitamin B12 in most plant-derived foods. As such, many vegans and vegetarians put themselves at risk for B12 deficiency or suboptimal B12 nutritional status. In these cases, dissolving one Bodhi Health Fast-Dissolving Vitamin B12 strip under your tongue each day can help ensure optimal B12 status over your lifetime.\u003c\/p\u003e","brand":"Bodhi Health Inc","offers":[{"title":"Default Title","offer_id":42365433151578,"sku":"CP400051","price":0.0,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0676\/2001\/2122\/files\/thumbnail_5_Pack_Display_B12_-_Edited.png?v=1760635817"},{"product_id":"bodhi-health-vitamin-b12-sublingual-1000mcg-30-pak","title":"Bodhi Health Vitamin B12 Sublingual, 30 Pack, 10 box Counter Display","description":"\u003cp\u003eRapid Absorption into the Bloodstream\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEnsure Your B12 Status Remains Optimal with Our Fast-Dissolving Sublingual (under the tongue) B12 Strips\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eVitamin B12 is a vital nutrient required by the body to make red blood cells (preventing anemia), which enables optimal energy production every minute of our lives. B12 is also necessary for the synthesis of brain chemicals (neurotransmitters) required for normal cognition, focus, mood stabilization, prevention of depression and to prevent the build-up of heart disease promoting “homocysteine” in the bloodstream, among other important function.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy Is Sub-Optimal Vitamin B12 Status So Common?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAging Process\u003c\/strong\u003e – in the aging process the stomach makes less acid (hydrochloric acid), which hinders the synthesis and secretion of intrinsic factor. Intrinsic factor is essential for vitamin B12 to get absorbed from the intestinal tract to the bloodstream. As such, many older persons absorb less vitamin B12 from the gut even if they take B12 supplements or consume B12-containing foods frequently.\u003c\/p\u003e\n\u003cp\u003eThis is why Bodhi Health’s Fast Dissolving Sublingual B12 Strips is so helpful for people over 45-50. The fast-dissolving strip allows vitamin B12 to get absorbed directly into the bloodstream once placed under the tongue, without the need of intrinsic factor. Our proprietary oral film strip allows for the fastest possible absorption of B12 (less than one minute in most cases) right into the bloodstream, helping to ensure optimal Vitamin B12 status in your body each day.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntacid Medications\u003c\/strong\u003e - Doctors often prescribe antacids, proton pump inhibitors and\/or histamine blockers to help older subjects who have digestive problems or reflux pain following meals. These drugs block the secretion or action of stomach acids, which in turn further reduces the secretion of intrinsic factor. Intrinsic factor is essential for the absorption of vitamin B12 from the intestinal tract into the bloodstream. Thus, patients taking these drugs are known to be at risk for vitamin B12 deficiency or sub-optimal vitamin B12 status. The daily use of Bodhi Health’s Sublingual B12 is the natural solution to prevent a decline in B12 status in these cases, as our Vitamin B12 strip is quickly absorbed (usually less than one minute) under the tongue directly into the bloodstream, bypassing the need for intrinsic factor.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChanges in Food Selection in Older Subjects and Shifts to More Plant-based Diets\u003c\/strong\u003e – It is well known that older subjects tend to eat fewer vitamin B12 containing foods (mostly meat-based foods) or smaller portions of these foods. This often leads to a significant decline in B12 status over time. As well, even though a more plant-based diet is desirable to help reduce risk of heart disease (cardiovascular disease) and certain cancers, there is no or very little vitamin B12 in most plant-derived foods. As such, many vegans and vegetarians put themselves at risk for B12 deficiency or suboptimal B12 nutritional status. In these cases, dissolving one Bodhi Health Fast-Dissolving Vitamin B12 strip under your tongue each day can help ensure optimal B12 status over your lifetime.\u003c\/p\u003e","brand":"Bodhi Health Inc","offers":[{"title":"Default Title","offer_id":42365434757210,"sku":"CP400006","price":0.0,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0676\/2001\/2122\/files\/B12_30_pack_Display_d7908e65-7842-46d2-9db4-0a957294b4de.jpg?v=1759567678"},{"product_id":"bodhi-health-sleep-sublingual-5mg-5-pak","title":"Bodhi Health Sleep Sublingual,  5 Pack, 20 Sleeve Counter Display","description":"\u003cp\u003e\u003cstrong\u003eFast-Acting Sleep Support\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBodhi Health’s Fast-Absorbing Sublingual Melatonin (Sleep) quickly dissolves under your tongue delivering melatonin directly into your bloodstream within minutes.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis provides a fast-acting effect that is facilitated by our proprietary oral strip technology, which is proven to delivery active ingredients into the bloodstream rapidly, once placed under the tongue (1).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eApproved Benefits of Melatonin:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHelps increase total sleep time in people suffering from sleep restriction or altered sleep schedule (e.g., shift work and jet lag).\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHelps to reduce the time it takes to fall asleep.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHelps to reset the body’s sleep-wake-cycle.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNatural, safe and non-habit-forming sleep aid.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWhy Is Sublingual Melatonin the Best Route of Administration?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eClinical studies show that oral melatonin supplements that you swallow are not absorbed well from the gut. In fact, some studies show that only 15% of the melatonin you swallow gets absorbed from the intestinal tract into the bloodstream (this also includes melatonin being quickly broken down by liver enzymes shortly after its absorption form the intestinal tract) (2) As such, oral melatonin supplements are a very inefficient approach to the use of melatonin as a sleep aid or to reset the body’s sleep-wake cycle.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther Important Reasons to Consider Melatonin (Sleep) Use After Age 40:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAge-related Decline in Melatonin Synthesis -\u003c\/strong\u003e Melatonin levels begin to decline in the body after puberty and by age 40 melatonin levels are more than 50% lower than they were at age 12-13. This is important because, in addition to sleep benefits, the body relies on melatonin for other important functions (Frontiers of Aging Neuroscience 2022. \u003ca rel=\"noopener\" href=\"https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2022.888292\/full\" target=\"_blank\"\u003ehttps:\/\/www.frontiersin.org\/journals\/aging-\u003c\/a\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2022.888292\/full\" target=\"_blank\"\u003eneuroscience\/articles\/10.3389\/fnagi.2022.888292\/full\u003c\/a\u003e\u003ca rel=\"noopener\" href=\"https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2022.888292\/full\" target=\"_blank\"\u003e)\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eSome of these functions include the following:\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImmune Support –\u003c\/strong\u003e many immune cells contain melatonin receptors that require melatonin stimulation for immune cells to function optimally throughout our lifetime (3).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtects Brain Cells from Free Radical Damage:\u003c\/strong\u003e Melatonin is a very important antioxidant in the brain, protecting brain cells from the damaging effects of free radicals that are involved in a variety of neurodegenerative diseases and brain aging (4),\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSmall Studies Show Improvement in Early-Stage Memory Loss:\u003c\/strong\u003e Several human studies have shown that patients with early-stage memory loss (mild cognitive impairment) exhibited significantly better performance in the Mini-Mental State Examination and the Cognitive Subscale of Alzheimer’s disease Assessment Scale after melatonin administration compared to the control group (who did not receive melatonin) (5).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProstate and Breast Health Support:\u003c\/strong\u003e Prostate and Breast cells are known to possess melatonin receptors. When melatonin binds to these receptors it enters these cells where it is shown to exert a numerous health-promoting effects of importance (6,7).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTurns-On Anti-Aging Sirtuin Genes –\u003c\/strong\u003e Experimental studies show that melatonin “turns on” (upregulates) anti-aging genes in human cells known as sirtuin genes (SIRT 1). Sirtuin gene activation is shown to help protect us against various age-related conditions and degenerative states associated with the aging process (8,9,10)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eBreakthrough Proprietary Oral Film Technology: (Frontiers of Pharmacology, 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31551785\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/31551785\/\u003c\/a\u003e),\u003c\/li\u003e\n\u003cli\u003eDeMuro RL et al. The absolute bioavailability of oral melatonin. J Clin Pharmacol.2000;40(7):781-4 \u003ca rel=\"noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10883420\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/10883420\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eCarrillo-Vico A. et al. Melatonin: Buffering the immune system. Int J Sci. 2023;14(4):8638-8683. \u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3645767\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3645767\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eGoo Lee J et al. The neuroprotective effects of melatonin: Possible role in the pathophysiology of neuropsychiatric disease. Brain Sci. 2019;9(10):285. \u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6826722\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6826722\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eCardinali D.P., et al. Therapeutic application of melatonin in mild cognitive impairment. Am J Neurodegener Dis. 2012;1(3):280-291. \u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3560473\/\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3560473\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMegerian M.F. et al. Melatonin and Prostate Cancer : Anti-tumor roles and therapeutic application. Aging Dis. 2023;14(3):840-857. \u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10187692\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10187692\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eGrant S.G. et al. Melatonin and breast cancer: Cellular mechanisms, clinical studies and future perspectives. Expert Rev Mol Med. 2009;11:e5. \u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4301735\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4301735\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eQin K et al. Melatonin promotes sirtuin 1 expression and inhibits IRE1-alpha-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes. Front. Pharmacol. 2022;13. \u003ca href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.940629\/full\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.940629\/full\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eRodrguez-Santana C et al. The relationship between clock genes, sirtuin 1, and mitochondrial activity in head and neck squamous cell cancer: Effects of melatonin treatment. Int J Mol Sci. 2023;24(19): 15030. \u003ca href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.940629\/full\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.940629\/full\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMayo J.C. et al. Melatonin and sirtuins : A “not-so unexpected” relationship. J Pineal Research. 2017;62e 12391. \u003ca href=\"https:\/\/digibuo.uniovi.es\/dspace\/bitstream\/handle\/10651\/43022\/jpi.12391.pdf?sequence=1\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/digibuo.uniovi.es\/dspace\/bitstream\/handle\/10651\/43022\/jpi.12391.pdf?sequence=1\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Bodhi Health Inc","offers":[{"title":"Default Title","offer_id":42365435215962,"sku":"CP400068","price":0.0,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0676\/2001\/2122\/files\/thumbnail_5_Pack_Display_Sleep_-_Edited.png?v=1760635865"},{"product_id":"bodhi-health-sleep-sublingual-5mg-30-pak","title":"Bodhi Health Sleep Sublingual, 30 Pack, 10 Box Counter Display","description":"\u003cp\u003e\u003cstrong\u003eFast-Acting Sleep Support\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBodhi Health’s Fast-Absorbing Sublingual Melatonin (Sleep) quickly dissolves under your tongue delivering melatonin directly into your bloodstream within minutes.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis provides a fast-acting effect that is facilitated by our proprietary oral strip technology, which is proven to delivery active ingredients into the bloodstream rapidly, once placed under the tongue (1).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eApproved Benefits of Melatonin:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHelps increase total sleep time in people suffering from sleep restriction or altered sleep schedule (e.g., shift work and jet lag).\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHelps to reduce the time it takes to fall asleep.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHelps to reset the body’s sleep-wake-cycle.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNatural, safe and non-habit-forming sleep aid.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWhy Is Sublingual Melatonin the Best Route of Administration?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eClinical studies show that oral melatonin supplements that you swallow are not absorbed well from the gut. In fact, some studies show that only 15% of the melatonin you swallow gets absorbed from the intestinal tract into the bloodstream (this also includes melatonin being quickly broken down by liver enzymes shortly after its absorption form the intestinal tract) (2) As such, oral melatonin supplements are a very inefficient approach to the use of melatonin as a sleep aid or to reset the body’s sleep-wake cycle.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther Important Reasons to Consider Melatonin (Sleep) Use After Age 40:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAge-related Decline in Melatonin Synthesis -\u003c\/strong\u003e Melatonin levels begin to decline in the body after puberty and by age 40 melatonin levels are more than 50% lower than they were at age 12-13. This is important because, in addition to sleep benefits, the body relies on melatonin for other important functions (Frontiers of Aging Neuroscience 2022. \u003ca href=\"https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2022.888292\/full\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/www.frontiersin.org\/journals\/aging-\u003c\/a\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2022.888292\/full\" rel=\"noopener\" target=\"_blank\"\u003eneuroscience\/articles\/10.3389\/fnagi.2022.888292\/full\u003c\/a\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2022.888292\/full\" rel=\"noopener\" target=\"_blank\"\u003e)\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eSome of these functions include the following:\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImmune Support –\u003c\/strong\u003e many immune cells contain melatonin receptors that require melatonin stimulation for immune cells to function optimally throughout our lifetime (3).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProtects Brain Cells from Free Radical Damage:\u003c\/strong\u003e Melatonin is a very important antioxidant in the brain, protecting brain cells from the damaging effects of free radicals that are involved in a variety of neurodegenerative diseases and brain aging (4),\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSmall Studies Show Improvement in Early-Stage Memory Loss:\u003c\/strong\u003e Several human studies have shown that patients with early-stage memory loss (mild cognitive impairment) exhibited significantly better performance in the Mini-Mental State Examination and the Cognitive Subscale of Alzheimer’s disease Assessment Scale after melatonin administration compared to the control group (who did not receive melatonin) (5).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProstate and Breast Health Support:\u003c\/strong\u003e Prostate and Breast cells are known to possess melatonin receptors. When melatonin binds to these receptors it enters these cells where it is shown to exert a numerous health-promoting effects of importance (6,7).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTurns-On Anti-Aging Sirtuin Genes –\u003c\/strong\u003e Experimental studies show that melatonin “turns on” (upregulates) anti-aging genes in human cells known as sirtuin genes (SIRT 1). Sirtuin gene activation is shown to help protect us against various age-related conditions and degenerative states associated with the aging process (8,9,10)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eBreakthrough Proprietary Oral Film Technology: (Frontiers of Pharmacology, 2019. \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31551785\/\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/31551785\/\u003c\/a\u003e),\u003c\/li\u003e\n\u003cli\u003eDeMuro RL et al. The absolute bioavailability of oral melatonin. J Clin Pharmacol.2000;40(7):781-4 \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10883420\/\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/10883420\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eCarrillo-Vico A. et al. Melatonin: Buffering the immune system. Int J Sci. 2023;14(4):8638-8683. \u003ca rel=\"noopener\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3645767\/\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3645767\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eGoo Lee J et al. The neuroprotective effects of melatonin: Possible role in the pathophysiology of neuropsychiatric disease. Brain Sci. 2019;9(10):285. \u003ca rel=\"noopener\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6826722\/\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6826722\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eCardinali D.P., et al. Therapeutic application of melatonin in mild cognitive impairment. Am J Neurodegener Dis. 2012;1(3):280-291. \u003ca href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3560473\/\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3560473\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMegerian M.F. et al. Melatonin and Prostate Cancer : Anti-tumor roles and therapeutic application. Aging Dis. 2023;14(3):840-857. \u003ca rel=\"noopener\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10187692\/\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10187692\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eGrant S.G. et al. Melatonin and breast cancer: Cellular mechanisms, clinical studies and future perspectives. Expert Rev Mol Med. 2009;11:e5. \u003ca rel=\"noopener\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4301735\/\" target=\"_blank\"\u003ehttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4301735\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eQin K et al. Melatonin promotes sirtuin 1 expression and inhibits IRE1-alpha-XBP1S-CHOP to reduce endoplasmic reticulum stress-mediated apoptosis in chondrocytes. Front. Pharmacol. 2022;13. \u003ca rel=\"noopener\" href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.940629\/full\" target=\"_blank\"\u003ehttps:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.940629\/full\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eRodrguez-Santana C et al. The relationship between clock genes, sirtuin 1, and mitochondrial activity in head and neck squamous cell cancer: Effects of melatonin treatment. Int J Mol Sci. 2023;24(19): 15030. \u003ca rel=\"noopener\" href=\"https:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.940629\/full\" target=\"_blank\"\u003ehttps:\/\/www.frontiersin.org\/journals\/pharmacology\/articles\/10.3389\/fphar.2022.940629\/full\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMayo J.C. et al. Melatonin and sirtuins : A “not-so unexpected” relationship. J Pineal Research. 2017;62e 12391. \u003ca rel=\"noopener\" href=\"https:\/\/digibuo.uniovi.es\/dspace\/bitstream\/handle\/10651\/43022\/jpi.12391.pdf?sequence=1\" target=\"_blank\"\u003ehttps:\/\/digibuo.uniovi.es\/dspace\/bitstream\/handle\/10651\/43022\/jpi.12391.pdf?sequence=1\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Bodhi Health Inc","offers":[{"title":"Default Title","offer_id":42365435543642,"sku":"CP400020","price":0.0,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0676\/2001\/2122\/files\/Melatonin_30_pack_Display_3b455e15-45b7-41c2-add1-4a9a13959759.jpg?v=1759567838"},{"product_id":"bodhi-sigg-water-bottle","title":"Bodhi Sigg Water Bottle 1L","description":"\u003cp\u003eBodhi Sigg Water Bottle 1 L\u003c\/p\u003e\n\u003cp\u003eMade in Switzerland\u003c\/p\u003e","brand":"Bodhi Health Inc","offers":[{"title":"Default Title","offer_id":42800905683034,"sku":"Bodhi_Bottle_1L","price":29.98,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0676\/2001\/2122\/files\/siggpic_3fa1ee8a-5264-4640-ba7c-6f3dbf93320d.jpg?v=1769024971"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0676\/2001\/2122\/collections\/Curcumin_5_display_06c2e6f0-9393-4ed7-8aea-6c2c28af7979.jpg?v=1774437192","url":"https:\/\/bodhihealth.com\/collections\/all-products-b-to-b.oembed","provider":"Bodhi Health Inc","version":"1.0","type":"link"}